Considering Switching from Mounjaro to Wegovy?
(Please check with us before ordering wegovy as each patient needs to be switched to an appropriate dose based on our formulation, don't pick a dose automatically as this may be changed).
Here’s everything you need to know from Pharmacy Express
If you’re currently using Mounjaro and are thinking about transitioning to Wegovy, you’re not alone. With recent changes in medication availability, price and treatment preferences, many patients are exploring new options that better suit their needs and goals.
At Pharmacy Express, we’re here to support you in making informed decisions about your care — including understanding how to safely and confidently move from one treatment to another.
Key Takeaways
- Both Mounjaro and Wegovy are weekly injectable GLP-1 receptor agonists that support weight loss by reducing appetite and slowing stomach emptying.
- Mounjaro also activates GIP receptors, making it effective for both weight management and blood sugar control in type 2 diabetes.
- Wegovy is specifically licensed for weight loss and is supported by strong clinical evidence.
- Transitioning between the two is safe when managed properly, usually requiring a short gap between doses.
- Patients often switch due to side effects, medication preferences, or changes in treatment plans.
What’s the Difference Between Mounjaro and Wegovy?
While both medications belong to the GLP-1 receptor agonist class, they have some key distinctions:
- Wegovy contains semaglutide, which mimics the GLP-1 hormone to help regulate hunger and fullness.
- Mounjaro contains tirzepatide, which mimics both GLP-1 and GIP hormones — supporting glucose regulation in addition to weight loss.
Both medications are injectable and administered once weekly, with gradual dose increases over time.
Comparable Results
Clinical Trial Results & Effectiveness
- The key STEP trials (e.g. STEP 1) underlying Wegovy’s approval demonstrate an average weight loss of ~14.9% over approximately 68 weeks when combined with diet and exercise. Approximately 86% of participants achieved at least 5% weight loss, about 70% achieved ≥10%, and nearly 50% achieved ≥15%—all statistically superior to placebo.
- A broader meta-analysis of six randomized controlled trials, including STEP data, found semaglutide 2.4 mg induced an average body weight decrease of 11.8% (~12.2 kg), reduced BMI by 4.5 kg/m², and waist circumference by 9.4 cm. It also improved blood pressure, glycemic control, lipid profiles, inflammation markers (CRP), and physical functioning.
These results are consistent with global findings and underpin MHRA and NICE approval in the UK.
In clinical trials, both medications have demonstrated significant weight loss outcomes:
- Wegovy has shown up to 14.9% body weight reduction.
- Mounjaro has shown up to 20.9hk.% weight reduction.
This means that, when used consistently and alongside a healthy lifestyle, both treatments offer effective support for weight loss.
Can You Switch from Mounjaro to Wegovy?
Yes — with clinical guidance, switching is both safe and straightforward.
At Pharmacy Express, we can help guide you through:
- Reviewing your current medication and dosage
- Discussing any side effects or concerns
- Determining an appropriate time to start Wegovy (typically a short gap, often around 7 days, is recommended)
- Adjusting your starting dose to suit your treatment history
It's important to note that Mounjaro and Wegovy are not interchangeable, so a guided transition is essential for both safety and continued effectiveness.
How the Process Works
- Stop Mounjaro: After your final dose, pause your injections.
- Wait 7 days: (as advised by your clinician).
- Start Wegovy: Begin on a dose that reflects your treatment history and tolerance, you may not need to start at the lowest dose but ask us before selecting which strength wegovy you need.
You’ll continue with weekly injections, with your prescriber adjusting doses if needed based on how you respond. (Please check with us before ordering wegovy as each patient needs to be switched to an appropriate dose based on our formulation, don't pick a dose automatically as this will be most likely changed).
Reasons People Make the Switch
- Tolerability: Some individuals may experience fewer side effects with one medication over the other.
- Treatment goals: If weight loss is your primary objective and you’re not managing diabetes, Wegovy may be a more streamlined option.
- Lifestyle fit: Everyone’s health journey is different — choosing a treatment that works best for you is key to long-term success.
What to Expect During the Transition
You’re unlikely to experience withdrawal symptoms during the transition, especially if you’re using the medications for weight management rather than diabetes. Any appetite-suppressing effects may continue for a short period even after stopping Mounjaro.
The most important thing is to stay consistent with your healthy habits during the transition and reach out if you need support.
Your Weight Loss Journey with Pharmacy Express
At Pharmacy Express, your health and comfort are our priority. If you're considering making the switch to Wegovy, we're here to:
- Review your current treatment
- Answer your questions and concerns
- Ensure a smooth, medically supervised transition
We’ll tailor your weight-loss plan based on your history and goals, and guide you at every step.
Ready to take the next step?
Contact our clinical team today or book a consultation to explore your options and make the move with confidence.
